Darek Gorecki

Biography

Darek Gorecki was born in Warsaw, Poland where he read medicine and obtained his PhD. His key research interest is pathogenesis of Duchenne muscular dystrophy. He started research in this area as a post-doctoral fellow in the Molecular Neurobiology Unit, University of Cambridge under Professor Eric A Barnard, FRS. He continued it at the Royal Free & University College Medical School in London working as a research fellow and later obtained a personal Wellcome Trust Research Career Development Fellowship. After moving to his present laboratory in Portsmouth he has worked as a Senior Lecturer, Reader and, since 2007, Professor of Molecular Medicine. He is the Director of Research in the School of Pharmacy and Biomedical Sciences. In 2011 he won Distinguished Fulbright Scholarship to work at Harvard Medical School, USA researching the role of specific ATP receptors in muscular dystrophy.

For more information about my research please visit my lab page.

Research interests

Pathogenesis and treatment of Duchenne muscular dystrophy, role of the dystrophin complex in the brain, purinoceptors, gene therapy using non-viral vectors.

Research outputs

2025

Deficient astrocyte homeostatic support contributes to brain impairment in Duchenne muscular dystrophy

Gorecki, D. C., Patel, A. M., Pomeroy, J., Verkhratsky, A.

26 Jun 2025, In: Neurochemical Research. 50, 4, 18p., 213

Research output: Article

Is dystrophin immunogenicity a barrier to advancing gene therapy for Duchenne muscular dystrophy?

Górecki, D. C., Kalinski, P., Pomeroy, J.

3 Apr 2025, In: Gene Therapy

Research output: Article

Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain

Pomeroy, J., Borczyk, M., Kawalec, M., Hajto, J., Carlson, E., Svärd, S., Verma, S., Bareke, E., Boratyńska-Jasińska, A., Dymkowska, D., Mellado-Ibáñez, A., Laight, D., Zabłocki, K., Occhipinti, A., Majewska, L., Angione, C., Majewski, J., Yegutkin, G. G., Korostynski, M., Zabłocka, B., Górecki, D. C.

20 Mar 2025, In: Molecular Medicine. 31, 1, 33p., 108

Research output: Article

2024

Investigating the involvement of C−X−C Motif Chemokine 5 and P2X7 purinoceptor in ectopic calcification in mouse models of Duchenne muscular dystrophy

Rumney, R. M. H., Pomeroy, J., Górecki, D. C.

1 Aug 2024, In: Journal of Cellular Biochemistry. 125, 8, p. 1-11, 11p., e30617

Research output: Article

The P2×7 receptor is a master regulator of microparticle and mitochondria exchange in mouse microglia

Falzoni, S., Vultaggio-Poma, V., Chiozzi, P., Tarantini, M., Adinolfi, E., Boldrini, P., Giuliani, A. L., Morciano, G., Tang, Y., Gorecki, D., Di Virgilio, F.

1 Jul 2024, In: Function. 5, 4, 16p., zqae019

Research output: Article